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Lincomycin has been shown to be active in vitro against the following microorganismshoweverthe safety and efficacy of Lincocin in treating clinical infections due to these organisms have not been established in adequate and well controlled trials.
The intravenous dose will be determined by the severity of the infectionFor serious infections doses of 600 mg of lincomycin2 mL of LINCOCINto 1 gram are given every 8 to 12 hoursFor more severe infections these doses may have to be increasedIn life-threatening situations daily intravenous doses of as much as 8 grams have been givenIntravenous doses are given on the basis of 1 gram of lincomycin diluted in not less than 100 mL of appropriate solutionsee Physical Compatibitiesand infused over a period of not less than one hour.
Lincomycin should be used with caution with neuromuscular blocking medications such as atracuriumTracriumpancuroniumPavulonrocuroniumZemuronsuccinylcholineAnectineand vecuroniumLincomycin may increase the effects of neuromuscular blockage and lead to respiratory depression.
Review of experience to date suggests that a subgroup of older patients with associated severe illness may tolerate diarrhea less wellWhen Lincocin is indicated in these patientsthey should be carefully monitored for change in bowel frequency.
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